HPA Axis Physiology and What “Cortisol Support” Suggests Cortisol is a glucocorticoid launched from the adrenal cortex under ACTH drive from the pituitary, itself driven by hypothalamic CRH. The axis is not a solitary on/off button: secretion is pulsatile, peaks in the morning in a normal circadian profile, and climbs further with emotional tons, rest limitation, hypoglycemia, swelling, and intense…
